The different forms of acute leukaemias in children are characterized by definite chromosomal abnormalities. Their high frequency and specific character affect the course of leukaemic process. The aim of the study was to detect the relation between chromosomal abnormalities and the course of the disease and to clarify the patients according to cytogenetic risk factors.

Materials and Methods: 35 patients with acute leukaemias were studied, 27 with lymphoblastic leukaemia and 8 with non-lymphoblastic leukaemias. They were taken under observation between 1980-1988. The age of the patients ranged from 1-16 years. During the analysis all chromosomal abnormalities and relation between normal and abnormal metaphases were taken into consideration. We also considered whether the patient had one normal, abnormal or mixed karyotype. In normal clones with increased chromosomal number it was significant whether cells contain more than 49 chromosomes, or whether their number was over 50, and which chromosome was implicated into the aberration most frequently. All these disturbances in relation with the clinical course of the disease and definition of their prognostic significance were studied. The analysis of bone marrow cells for cytogenetic study of primary patients were carried out. The bone marrow smears were painted routinely and «G» strips method was used. Statistical significance was calculated by probit-analysis. /Emmanouel N., L.S. Evseeko, 1970/ Compare to each others t ½ log distribution parameters t ½ at this time, where 50% of survivals reached and it is defined by antilogarithmic table. A«P» value of less than 0.001 was considered significant.

Discussion: The results achieved make it possible to classify the patients in to different risk groups on the basis of cytogenetic dates.Table

Table 1
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