Elevated serum bilirubin (SB) 10.9 mg/dl was noted in a six hr old, 3969g term infant with severe BO disease (Hct 29%, Hct 40%). Intensive photoRx resulted in only a modest fall in rate of SB rise; Ex appeared inevitable. Hourly BOX feedings (60 Units/kg/d), begun at 22 hrs were associated with decrease stool bile pigments and more rapid than expected fall in SB. No Ex needed. Findings in this infant are presented in comparison to those in the seven other term infants with BO disease Rx at PA H from 1991 to 1995. All needed Ex. Their SB and age at Ex (mean ± SD), were 20.2 mg/dl ± 2.4; 28.6 hs ± 7.3 resp.(See Table).
No Ex needed in BOX baby. We conclude BOX is promising and deserves further study.
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Johnson, L., Bhutani, V., Abbasi, S. et al. Need for Exchange Transfusion (Ex) in Infants with Severe BO Disease Treated with Intensive PhotoRx Alone (1991-95) or with BOX Plus Intensive PhotoRx(1996). 924. Pediatr Res 41 (Suppl 4), 156 (1997). https://doi.org/10.1203/00006450-199704001-00943
Issue Date:
DOI: https://doi.org/10.1203/00006450-199704001-00943
