Background/aim: The application of IGF-I for treatment of uremic growth failure may be limited because of the risk of hypoglycemia. We investigated the hypoglycemic effects of IGF-I in uremia with or without concomitant GH administration.
Subjects/interventions: 120 g female SD rats were made uremic (U) by 5/6 nephrectomia Four groups of 6 animals were treated with different doses of IGF-I over 7 days. Thereafter 4mg/kg/d IGF-I and 10 IU/kg/d GH were combined for 12 days in U and pair-fed control (C) rats.
Results: The hypoglycemic effect of IGF-I increased parallel to the dose, but after 1 week the hypoglycemia declined.(Table: serum glucose levels (mg/dl) two hours after injections in U rats).
Hypoglycemia in U and C could be diminished by concomitant injection with GH. Mean serum glucose level being increased by 65% compaired to IGF-I-alone treated animals.
Conclusion: IGF-I leads to hypoglycemia in U, which becomes less expressed after prolonged administration GH attermates the hypoglycemic effect of IGF-I.
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Kovacs, G., Kovacs, J., Oh, J. et al. IGF-I Induced Hypoglycemia and Prevention by Growth Hormone (GH) in Uremic Rats 136. Pediatr Res 40, 537 (1996). https://doi.org/10.1203/00006450-199609000-00159
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DOI: https://doi.org/10.1203/00006450-199609000-00159
