OBJECTIVE: to evaluate the effect of nasal high frequency oscillation(nHFO) during nasal continuous positive airway pressure (nCPAP) in newborn infants with moderate respiratory insufficiency we performed a non controlled observational study.
PATIENTS AND METHODS: 10 patients (gestational age 25-37 weeks, birth weight 570-3100 gram, age 4 hrs - 21 days) were treated with nHFO. We used an Infant Star ventilator, initial setting mean airway pressure 4-8 cm H2O and amplitude ΔP 35-45 mm H2O. A tube (inner diameter 2,5-3,0 mm) was placed nasally at a depth of 3 cm. Indications for nHFO were clinical signs of respiratory distress, increasing oxygen need and/or CO2 retention during prior nCPAP.
RESULTS: In 9 patients we observed a decline in pCO2 within 2,5 hours(Wilcoxon, p=0,013; figure). There was no effect on oxygen need, heart rate or blood pressure.
Figure 1
CONCLUSION: nHFO reduces pCO2 in selected newborn infants with moderate respiratory insufficiency. A randomized study should be done to determine the exact value of nHFO.
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Brouwer, E., van der Hoeven, M., Gavilanes, D. et al. NASAL HIGH FREQUENCY OSCILLATION AND NASAL CONTINUOUS POSITIVE AIRWAY PRESSURE FOR RESPIRATORY INSUFFIENCY IN NEWBORN INFANTS 1946. Pediatr Res 39 (Suppl 4), 327 (1996). https://doi.org/10.1203/00006450-199604001-01970
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DOI: https://doi.org/10.1203/00006450-199604001-01970
