Fetal intervention for infants with birth defects is a recent development in perinatal care. The Fetal Treatment Center at UCSF has performed fetal surgical interventions in cases of congenital cystic adenomatoid malformations(CCAM) and in cases of congenital diaphragmatic hernias (CDH). Twelve infants have survived. Four infants had CCAM; eight infants had Left CDH. We have been able to follow the outcome of seven infants (# 1-7) to date with formal evaluations (4 CCAM, 3 LCDH); and we have obtained information on five infants(#8-12) from primary care physicians: Table

Table 1
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One infant (#12) suffered child abuse and had a CNS hemorrhage with resultant frequent seizures. The remaining eleven infants are without major neurologic abnormalities, with one suspect for hypertonicity in the lower extremities. Three infants have some mild developmental delay (two cognitive, one motor) associated with prematurity or rehospitalizations.