Abstract
ABSTRACT: Peripheral-type (mitochondrial) benzodiazepine receptors (PTBR) were studied in the brain and peripheral organs (kidney, liver, and testis) of normal male mice (CD-1/Y) and the congenially hyperammonemic sparse fur (spf/Y) mouse. Radioligand binding assays were performed with [3H]PK 11195, a ligand with high selectivity and affinity for PTBR. Densities (maximal number of binding sites) of [3H]PK 11195 binding sites were greatest in kidney, followed by liver, testis, and brain. Densities of [3H]PK 11195 binding sites were significantly increased in all tissues of spf mice compared with control animals. In view of the localization of PTBR on the outer mitochondrial membrane, changes in PTBR in spf mouse tissues may modulate the altered mitochondrial function and oxidative metabolism, in brain and peripheral tissues, in congenital OTC deficiency. The positron emission tomography ligand 11C-PK 11195 could find an application in the assessment of end organ dysfunction in this disorder.
Similar content being viewed by others
Article PDF
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Raghavendra Rao, V., Qureshi, I. & Butterworth, R. Increased Densities of Binding Sites for the Peripheral-Type Benzodiazepine Receptor Ligand [3H]PK 11195 in Congenital Ornithine Transcarbamylase-Deficient Sparse Fur Mouse. Pediatr Res 34, 777–780 (1993). https://doi.org/10.1203/00006450-199312000-00016
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1203/00006450-199312000-00016
This article is cited by
-
The neurosteroid system: an emerging therapeutic target for hepatic encephalopathy
Metabolic Brain Disease (2007)
-
Ornithine transcarbamylase deficiency: Pathogenesis of the cerebral disorder and new prospects for therapy
Metabolic Brain Disease (1997)
-
Tissue-specific alterations of binding sites for peripheral-type benzodiazepine receptor ligand [3H]PK11195 in rats following portacaval anastomosis
Digestive Diseases and Sciences (1994)
-
Densities of binding sites for the “peripheral-type” benzodiazepine receptor ligand3H-PK11195 are increased in brain 24 hours following portacaval anastomosis
Metabolic Brain Disease (1994)