Abstract
Binding of 125I-ICF-I to red blood cells (RBC) was determined in 12 prepubertal boys aged 7-9 yrs, 6 with short stature ( ≤ 2 SD height) and 6 with tall stature ( ≥ 2 SD height). Concomitantly blood hCH, IGF-I and GH-binding protein (BP) was determined. The results (mean ± SD) are:
In the present pilot study it was found that 125I-ICF-I receptor binding does not correlate with extreme short or tall heights as does scrum IGF-I and CH-BP. The ability of ICF-I to stimulate uptake of (H) amino-iso-butyric acid (AIB) by fibroblasts of the same patients is being performed.
Supported in part by a Nordisk (ESPE) grant.
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Eshet, R., Dux, Z., Klinger, B. et al. 108 IGF-BINDING TO READ BLOOD CELLS OF SIIORT AND TALL BOYS. COMPARIOSON WITH CH-BINDING PROTEIN LEVELS. Pediatr Res 24, 535 (1988). https://doi.org/10.1203/00006450-198810000-00129
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DOI: https://doi.org/10.1203/00006450-198810000-00129