Abstract
Bronchial hyperreactivity is often present in CF patients, but little is known about its causes. Therefore, in 80 outpatients with CF (age 5-34y) Aspergillus IgE antibodies, basic lung function parameters and bronchial reactivity to salbutamol inhalation were measured. Results were analysed using multiple regression for age, sex, weight as percentile for height (indicating general condition) and Aspergillus RAST.
In 55% of patients Aspergillus IgE was present, 22,5% had RAST Class 3 or 4. In addition to the known good correlation between basic lung function parameters and weight percentiles (p<0.01) we found an independent negative influence of age on FVC, FEV1, MEF50%VC and sRAW (p < 0.05), and of Aspergillus RAST on FEV1 MEF50%VC RV, RV/TLC. Bronchodilator sensitivity did not correlate significantly with age and weight (p > 0.5). However, Aspergillus RAST did significantly correlate with bronchodilator reactivity of sRAW (p < 0.01) and MEF50%VC (p < 0.05).
These results would indicate that bronchial reactivity in CF is often caused by hypersensitivity against Aspergillus and not related to general condition or age.
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Nicolai, T., Arleth, S., Bertele, R. et al. 128: CORRELATION OF IgE ANTIBODIES TO ASPERGILLUS FUMIGATUS WITH BRONCHODILATOR SENSITIVITY IN CYSTIC FIBROSIS (CF). Pediatr Res 24, 282 (1988). https://doi.org/10.1203/00006450-198808000-00153
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DOI: https://doi.org/10.1203/00006450-198808000-00153