Abstract
The progression of CRF is accelerated with a high protein (Pr) intake, however, the mechanism and the causal Pr-components are unknown. One factor might be Pr-induced hypercalciuria with calcification of the residual renal tissue. Since calciun(Ca)excretion is related to the Saa- and sulfate(Si)-content of ingested Pr, we investigated the influence of diets with different Pr- and Saa-content on GFR and renal tissue-Ca(RTca) in rats with CRF. The animals were fed for 4 weeks with either:1.high Pr diet(HP 32%,Saa:1,45%) 2.low Pr(LP8%, Saa:0,46%) 3.LP+0,89% met(LPSaa)or 4.LP(Soja 10%)+0,22% of taurine (LPlau, Saa:0,46%). Energy,Ca and phosphate (Pi)was equal in all diets. GFR(Ccr) and BUN were measured before(a) and after(p), plasma-Ca,Si,Pi and RTca after the feeding period. Results (means;P(CaSiPi)= ion product of plasma Ca,Si,Pi).
P(CaSiPi) was positively correlated with RTca and inversely with GFR.
Conclusion: The negative effect of high protein on renal function in CRF might partially be due to a high Saa-content, resulting in an increased sulfate production and renal calcification.
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Michalk, D., Leitz, R. 90 INFLIENCE OF SULFUR AMIND ACIDS (Saa) ON RENAL TISSLE CALCIFICATION AND THE COURSE CF CHRONIC RENAL FAILURE (CRF). Pediatr Res 24, 275 (1988). https://doi.org/10.1203/00006450-198808000-00116
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DOI: https://doi.org/10.1203/00006450-198808000-00116