Abstract
The literature shows that most of the antiepileptic drugs may produce adverse effects on treated patients. Previously we have demonstrated that plasmatic albumin (A) levels, phosphate (P) levels and alcaline phosphatase (AP)activity in children with phenobarbital (PB) treatment were significantly different compared to the control group (p<0.005, p<0.005 y p<0.001, respectively). The purpose of this investigaticn is to study the use of PB in a group of patients and correlate the total and free fractions of this drug with their nutritional status and biochemical parameters. Our results show that in the wellnourisned patients receiving PB, levels of serum A are reduced in 24.3% of them (x=3,9g/dl ± 0.34), and the levels of plasmatic P were also reduced in 20,7% of them (x= 4.4mg/dl ±0.56). Moreover, in the same group, AP activity increased in 44.8% (x= 510 U/L ± 134), and the glutamic oxalaoetic transaminase (TCOT) activity ircreased in 32,1% (x= 19.6 U/L ± 4.3) of the patients. In those with severe malnutrition, the % of them that showed low levels of plasmatic A increased to 42.8% (x= 3.7 ± 0.56) and the P levels to 46.2% (x= 3.9 ± 0.79). A significant difference of P levels was found between both groups (p<0.025), but the levels of TGOT and A were rot different. These results indicate that the free fraction of PB does nor vary with changes in the nutritional status and strongly suggest that, besides the monitoring of the drug, the necessity of measuring some biochemical parameters for a better clinical control of the patient.
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Salazar, T., Novoa, F., Peñaloza, L. et al. 8. PHENOBARBETAL: RELATIONSHIP WITH NUTRITIONAL STATUS AND BIOCHEMICAL PARAMETERS. Pediatr Res 23, 648 (1988). https://doi.org/10.1203/00006450-198806000-00031
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DOI: https://doi.org/10.1203/00006450-198806000-00031