Abstract
ABSTRACT: We evaluated the hypothesis that increased endogenous opioid activity mediates part or all of the left ventricular contractile and pump dysfunction previously demonstrated in HCl-induced metabolic acidemia. Eighteen Western newborn lambs were catheterized and instrumented; pacing wires were sutured to the right atrial appendage; a catheter mounted micromanometer pressure transducer was inserted into the left ventricle; and a 2.5 F thermistor was inserted into the distal abdominal aorta. The lambs were studied 3 days after surgery. Metabolic acidemia was produced with an infusion of 0.5 N HCl into the inferior vena cava. Inhibition of endogenous opioids was achieved with a bolus of 2 mg/kg of intravenous naloxone, which was demonstrated to inhibit morphine sulfate-induced myocardial dysfunction. The effects of opioid inhibition were contrasted with our previously published results after restoration of a normal arterial pH with intravenous sodium bicarbonate. In agreement with our previous study, we found that reducing the arterial pH from 7.41 ± 0.01 to 6.97 ± 0.04 was associated with a 45% reduction in cardiac output which resulted from a 50% reduction in stroke volume. These changes in turn were mediated by a 35% reduction in the maximal first derivative of left ventricular pressure and/or a 63% increase in systemic vascular resistance which we used to estimate contractility and afterload, respectively. Left ventricular end diastolic pressure increased during acidemia. Although opioid inhibition produced a consistent increase in the maximal first derivative of left ventricular pressure, this increase was relatively small and was not associated with a significant change in cardiac output, stroke volume, or systemic vascular resistance. In contrast, restoration of a normal arterial pH was associated with increases in cardiac output, heart rate, stroke volume, and dP/dt to greater than control values, as well as a normalization of systemic vascular resistance. These hemodynamic changes were not attributable to direct effects of naloxone. Herein we suggest that although opioids may exert a small role in mediating the contractile dysfunction that occurs during HC- induced metabolic acidemia, there is no apparent influence of opioids on pump performance. Opioids participate very little in the myocardial dysfunction of this model of metabolic acidemia in lambs.
Similar content being viewed by others
Article PDF
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Fisher, D., Dreyer, W., Tate, C. et al. Endogenous Opioids Do Not Mediate HCl-Induced Myocardial Dysfunction. Pediatr Res 23, 643–646 (1988). https://doi.org/10.1203/00006450-198806000-00023
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1203/00006450-198806000-00023