Abstract
ABSTRACT. Infantile Refsum's disease is characterized by high levels of phytanic acid and the absence of normal hepatic peroxisomes. We investigated the in vivo influence of phytol, a precursor of phytanic acid, on peroxisomes by both biochemical and morphological methods. Enhanced supply of phytol in the diet of adult mice causes proliferation of hepatic peroxisomes. The peroxisomal β-oxidizing capacity as well as exchanges of acyl moieties between peroxisomes and mitochondria are raised around 5- and 2- fold, respectively. In parallel a 1.5-fold increase of total catalase and mitochondrial butyryl-CoA dehydrogenase activities occurs, whereas peroxisomal urate oxidase and glycolate oxidase remain normally active. Serum triglyceride levels are decreased after 3 wk of phytol feeding; serum cholesterol levels remain unaffected. Phytol feeding also induces peroxisome proliferation in duodenal epithelium, in myocardium and in skin sebaceous glands, but not in kidney.
Similar content being viewed by others
Article PDF
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Van Den Branden, C., Vamecq, J., Wybo, I. et al. Phytol and Peroxisome Proliferation. Pediatr Res 20, 411–415 (1986). https://doi.org/10.1203/00006450-198605000-00007
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1203/00006450-198605000-00007
This article is cited by
-
Functional-metabolic coupling in distinct renal cell types coordinates organ-wide physiology and delays premature ageing
Nature Communications (2023)
-
Dysregulation of the NUDT7-PGAM1 axis is responsible for chondrocyte death during osteoarthritis pathogenesis
Nature Communications (2018)
-
Phytol-based novel adjuvants in vaccine formulation: 1. assessment of safety and efficacy during stimulation of humoral and cell-mediated immune responses
Journal of Immune Based Therapies and Vaccines (2006)
-
In situ heterogeneity of peroxisomal oxidase activities: An update
The Histochemical Journal (1996)
-
Liver pathology and immunocytochemistry in congenital peroxisomal diseases: a review
Journal of Inherited Metabolic Disease (1991)