Abstract
The aim of this study was to test the possibility that T supplementation could increase the absorption of a FMT in CF. In a cross-over design study four CF patients (12.1±2.6 yrs) and 3 controls received placebo (P) or T (30 mg/kg/j) for two 1-week periods a month apart, followed by a FMT (51 g/1.73 m2 of triglycerides (TG) containing 60% of 18:2). Blood samples were drawn at 0,1,2,3,5,8 hrs. Tabulated results are expressed as the change in total TG (Δ % = peak increase), as TG area under the curve (AUC = mg·h/dl) and as the total amount of C 18:2 (mg %).
The difference of TG-AUC on and off T in CF was significantly (p<.05) correlated with the degree of steatorrhea, the Shwachman score and the weight percentiles. Two facts ruled out an endogenous origin of the above mentioned data: chylomicrons had a fatty acid pattern similar to that of FMT and their peak occurred simultaneously with TG and 18:2 peaks. These results suggest that T supplementation could be used as an adjuvant form of therapy in CF, particularly in patients with a severe steatorrhea.
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Belli, D., Levy, E., Lenaerts, C. et al. INCREASED ABSORPTION OF A FATTY MEAL TEST (FMT) IN CYSTIC FIBROSIS (CF) PATIENTS ON TAURINE (T). Pediatr Res 20, 694 (1986). https://doi.org/10.1203/00006450-198607000-00053
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DOI: https://doi.org/10.1203/00006450-198607000-00053