Abstract
The safety and immunogenicity of RIT-4237 live attenuated rotavirus (bovine strain) vaccine were established (1). During the epidemic-free months of July and August 84, maternal and cord blood were obtained from 150 giving-birth mothers and their newborns. After informed consent, 57 newborns were vaccinated orally at birth and at one and two months; 42 infants completed the study. As the vaccine is known labile at low pH (2), gastric acidity was measured at each vaccination. Serum samples for RV-antibodies and faecal samples for RV detection were obtained at each vaccination. RV-antibodies were also assayed in breast-milk. No adverse reaction was observed.
The “take” of the vaccine was estimated by RV-seroneutralizing specific antibodies. Sero-conversion occurred in 28/42 (67%) infants: 8/42 (19%), 9/42 (21%) and 11/42 (27%) after first, second and third vaccinations respectively. No booster reaction was observed. RV-antibodies were low in breast-milk. Whereas there was no difference in gastric pH the geometric mean titer was clearly different in the two groups of responders and non-responders.
Conclusions: 1) Gastric acidity and breast-milk RV-antibodies do not seem to interfere with the “taKe” of the vaccine. 2) Optimal time for vaccination depends mostly on maternal RV-antibodies interference and therefore on geographical immunity conditions. 3) A multiple dose scheme is advisable.
(1) Vesikari et al. Lancet ii, 807, 1983
(2) VesiKari et al. Lancet ii, 700, 1984
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Cadranel, S., Zeghlache, S., Jonkheer, T. et al. ADMINISTRATION OF MULTIPLE DOSES OF ROTAVIRUS (RV) VACCINE RIT-4237 TO NEWBORNS. Pediatr Res 20, 691 (1986). https://doi.org/10.1203/00006450-198607000-00038
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DOI: https://doi.org/10.1203/00006450-198607000-00038