Abstract
ABSTRACT: Glycerol 3-phosphate is an initial metabolite in the biosynthesis of phosphoglycerides and triacylglycerols. Both glycerol and glucose are precursors of glycerol 3-phosphate. Cultured skin fibroblasts from patients with glycerol kinase deficiency utilized glucose, but not glycerol in the biosynthesis of phosphoglycerides and triacylglycerols. Phosphoglyceride and triacylglycerol biosynthesis in glycerol kinase deficiency fibroblasts is not diminished by the inability to use glycerol as a precursor of glycerol 3- phosphate.
Similar content being viewed by others
Article PDF
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Bartley, J., Ward, R. Glycerol Kinase Deficiency Inhibits Glycerol Utilization in Phosphoglyceride and Triacylglycerol Biosynthesis. Pediatr Res 19, 313–314 (1985). https://doi.org/10.1203/00006450-198503000-00012
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1203/00006450-198503000-00012