Abstract
ABSTRACT: The nature of the lipases released into the circulation during low level continuous infusion of heparin (1 unit/ml total parenteral nutrition) and after bolus heparin injection (10 units/kg) was investigated in a group of 11 low birth weight infants (gestational age 27–34 wk, and postnatal age of 7–26 days) receiving total parenteral nutrition with Intralipid (0.5 g/kg). Hepatic lipase and extrahepatic lipoprotein lipase were differentiated with the aid of an antibody specific for human hepatic lipase. The data show that continuous low level heparin infusion leads to a constant baseline postheparin lipolytic activity of 0.77 ± 0.18 μmol free fatty acids released per milliliter serum per hour. Bolus heparin injection leads to peak lipolytic activity levels of 3.77 ± 0.46 μmol free fatty acids per milliliter serum per hour, 10 min after injection. About two-thirds of the total postheparin lipolytic activity was of the hepatic type during low level continuous infusion or after bolus injection of heparin.
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Zaidan, H., Dhanireddy, R., Hamosh, M. et al. Lipid Clearing in Premature Infants during Continuous Heparin Infusion: Role of Circulating Lipases. Pediatr Res 19, 23–25 (1985). https://doi.org/10.1203/00006450-198501000-00007
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DOI: https://doi.org/10.1203/00006450-198501000-00007