Abstract
To evaluate the cardiovascular effects of FPL57231 on the early phase of GBS, paralyzed, mechanically ventilated piglets received a continuous IV infusion of GBS (4×108 org/kg/min) while aortic (AoP) and pulmonary artery pressures (Ppa) were measured q 15 min ('). Cardiac output (CO) was measured by thermodilution. Control animals (C) (n=3) (X+SD;wt, 3026±385g;age 10±2d) received only GBS. Treatment aninals (T) (n=4) (wt, 2646±493g;age 11±3d) received 1 mg/kg/min × 120′ of FPL57231, begining 15′ after infusion of GBS began. (*p<.05; **p,<.001)
AoP was not statistically different during this period for (C) or (T). Calculated pulmonary and systemic (SVR) vascular resistences were both lower in (T) (p<.03) from 30′ - 60′. SVR was not statistically different for (C) or (T) when base was compared to 60′. pH deteriorate (p<.01) by 60′ in (C), while there were no significant pH change in (T). (C) survived 113±26′ vs 187±50′ (p=.07) for (T). These data suggest that leukotrienes may affect the early cardiovascular manifestations of GBS.
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Goldberg, R., Suguihara, C., Steitfeld, M. et al. 1391 EFFECTS OF LEUKOTRIENE ANTAGONIST FPL57231 ON THE A EARLY HEMODYNAMIC MANIFESTATIONS OF GROUP B BETA STREPTOCOCCAL SEPSIS (GBS) IN PIGLETS. Pediatr Res 19, 342 (1985). https://doi.org/10.1203/00006450-198504000-01415
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DOI: https://doi.org/10.1203/00006450-198504000-01415