Abstract
Summary: Total intracellular Ca2+ and 45Ca2+ uptake has been studied in blood platelets from subjects with Down's syndrome and matched controls. In Down's subjects, Ca2+ levels (85.5 ± 5.9 nmol/10-9 platelets) were significantly lower than controls, 174 ± 10.0 nmol/10-9 (p < 0.0005). A similar reduction was seen in calcium uptake (Down's platelets, 0.79 ± 0.06 nmol/10-9 platelets; controls, 1.17 ± 0.07 nmol/10-9 platelets, p < 0.005). The low levels of intracellular Ca2+ may be related to decreased granular storage of serotonin, and the decreased Ca2+ uptake with impaired transport by intracellular Ca2+-accumulating organelles such as the dense tubular system.
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Mccoy, E., Sneddon, J. Decreased Calcium Content and 45Ca2+ Uptake in Down's Syndrome Blood Platelets. Pediatr Res 18, 914–916 (1984). https://doi.org/10.1203/00006450-198409000-00024
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DOI: https://doi.org/10.1203/00006450-198409000-00024