Abstract
In acute lymphoblastic leukaemia antiblastic therapy is usually discontinued after 3-5 years of complete remission. It is, therefore, of particular interest to increase our knowledge of the subsequent course of events in these cases.
We present a girl of 7 years, affected with A.L.L. and treated with chemotherapy for 3 years. 4 months following the cessation of therapy she presented with photophobia, perikeratic injection of the left eye and copious exudate in the anterior chamber. Local therapy (cortisone - atropine) produced a brief remission. At the third recurrence of symptoms, cytological examination of the exudate revealed the presence of numerous lymphoblasts.
Radiotherapy produced a complete, lasting remission, still persisting after an interval of 5 months.
The eye can be considered a “Pharmacological Sanctuary”, analogous with the C.N.S. and testis, and could be a possible site of localisation also in patients after completion of therapy.
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Masera, G., Caraelli, V., Uderzo, C. et al. LEUKAEMIC HYPOPION IN ACUTE LYMPHOBLASTIC LEUKAEMIA AFTER CESSATION OF THERAPY. Pediatr Res 12, 68 (1978). https://doi.org/10.1203/00006450-197801000-00052
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DOI: https://doi.org/10.1203/00006450-197801000-00052