Abstract
Circadian rhythm of serum proline was studied in three families with hereditary nephritis. In all members of the families EEG and audiometric investigation were carried out. Proline in the serum was estimated using O'Brien spectro photometric method. In our laboratory, this method, compared with the method of chromatography on ion exchangers have given a good correlation. In persons with normal values of serum proline their circadian periodicity was displayed with peak values at 12-15h and 21h, small reversal peak at 18h and lowest values at 3h. Hyperprolinaemia has not always been easily marked in the members of the families with hereditary nephritis, if proline was estimated in the morning blood samples, but it was expressed in different time intervals during a day or night. Hyperprolinaemia coincides more with kidney disease, but in one family there was a frequent association of hyperprolinaemia and deafness, but without nephritis. These observations indicate that it is necessary to repeat the examinations of serum proline periodically during day and even at night in order to confirm hyperprolinaemia.
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Čvorić, A. Circadian periodicity of serum proline in hereditary nephritis.. Pediatr Res 8, 895 (1974). https://doi.org/10.1203/00006450-197411000-00017
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DOI: https://doi.org/10.1203/00006450-197411000-00017