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Apoptosis promotes early tumorigenesis

Oncogene volume 30, pages 1851–1854 (2011)Cite this article

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Abstract

One hallmark of cancer is intrinsic or acquired resistance to apoptosis. Surprisingly, recent studies demonstrate that CD95/Fas/Apo1 and p53 upregulated mediator of apoptosis/PUMA (potent inducers of the death receptor and the mitochondrial apoptotic pathways, respectively) promote tumorigenesis. These findings provide important insights into the multifaceted roles of apoptosis in tumorigenesis.

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Acknowledgements

We appreciate ongoing discussions with Drs Bennett Van Houten, Douglas Green, Charleen Chu, and Lin Zhang about the issues of apoptosis and autophagy.

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Authors and Affiliations

  1. Department of Surgery, Hillman Cancer Center, University of Pittsburgh Cancer Institute, University of Pittsburgh, Pittsburgh, PA, USA

    D Tang, M T Lotze, R Kang & H J Zeh

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  1. D Tang
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  2. M T Lotze
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  3. R Kang
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  4. H J Zeh
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Correspondence to M T Lotze.

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Tang, D., Lotze, M., Kang, R. et al. Apoptosis promotes early tumorigenesis. Oncogene 30, 1851–1854 (2011). https://doi.org/10.1038/onc.2010.573

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