Abstract
The mucin 1 (MUC1) oncoprotein is overexpressed by diverse human cancers; however, it has remained largely unclear how MUC1 contributes to tumorigenesis. In this issue of Oncogene and in concert with published work, Behrens et al. report that the MUC1 receptor subunit activates genes involved in invasion, angiogenesis and metastasis.
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References
Behrens ME, Grandgenett PM, Bailey JM, Singh PK, Yi C-H, Yu F et al. (2010). The reactive tumor microenvironment: MUC1 signaling directly reprograms transcription of CTGF. Oncogene 29: 5667–5677).
Deng YZ, Chen PP, Wang Y, Yin D, Koeffler HP, Li B et al. (2007). Connective tissue growth factor is overexpressed in esophageal squamous cell carcinoma and promotes tumorigenicity through beta-catenin-T-cell factor/Lef signaling. J Biol Chem 282: 36571–36581.
Huang L, Chen D, Liu D, Yin L, Kharbanda S, Kufe D . (2005). MUC1 oncoprotein blocks GSK3beta-mediated phosphorylation and degradation of beta-catenin. Cancer Res 65: 10413–10422.
Khodarev N, Ahmad R, Rajabi H, Pitroda S, Kufe T, McClary C et al. (2010). Cooperativity of the MUC1 oncoprotein and STAT1 pathway in poor prognosis human breast cancer. Oncogene 29: 920–929.
Khodarev N, Pitroda S, Beckett M, MacDermed D, Huang L, Kufe D et al. (2009). MUC1-induced transcriptional programs associated with tumorigenesis predict outcome in breast and lung cancer. Cancer Res 69: 2833–2837.
Kufe D . (2009). Mucins in cancer: function, prognosis and therapy. Nat Rev Cancer 9: 874–885.
Pitroda S, Khodarev N, Beckett M, Kufe D, Weichselbaum R . (2009). MUC1-induced alterations in a lipid metabolic gene network predict response of human breast cancers to tamoxifen treatment. Proc Natl Acad Sci USA 106: 5837–5841.
Raina D, Ahmad R, Joshi M, Yin L, Wu Z, Kawano T et al. (2009). Direct targeting of the MUC1 oncoprotein blocks survival and tumorigenicity of human breast carcinoma cells. Cancer Res 69: 5133–5141.
Ramasamy S, Duraisamy S, Barbashov S, Kawano T, Kharbanda S, Kufe D . (2007). The MUC1 and galectin-3 oncoproteins function in a microRNA-dependent regulatory loop. Mol Cell 27: 992–1004.
Wei X, Xu H, Kufe D . (2005). Human MUC1 oncoprotein regulates p53-responsive gene transcription in the genotoxic stress response. Cancer Cell 7: 167–178.
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Kufe, D. Oncogenic function of the MUC1 receptor subunit in gene regulation. Oncogene 29, 5663–5666 (2010). https://doi.org/10.1038/onc.2010.334
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DOI: https://doi.org/10.1038/onc.2010.334
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