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Positive and negative influences of regulatory T cells on tumour immunity

Oncogene volume 27, pages 5886–5893 (2008)Cite this article

Abstract

Clinicians and scientists have long questioned whether the immune system has a role in destroying cancerous tissue. Studies performed in animal models have, however, recently revealed that the immune system can, at least in principle, effectively control tumours. In parallel with these findings, a large body of evidence indicates that although the immune system has the capacity to control tumours, there are also regulatory mechanisms that subdue these responses. A major challenge of tumour immunotherapy, therefore, is to find ways of disabling these regulatory functions while restoring or priming any immune responses that are protective.

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Acknowledgements

AMG is a Medical Research Council Non-Clinical Senior research Fellow and AKS is funded by the Association for International Cancer Research and by the NIHR Biomedical Research Centre. We thank Nick Willcox and Kerstin Lühn for carefully reading the manuscript.

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  1. Department of Medical Biochemistry and Immunology, School of Medicine, Cardiff University, UK

    A M Gallimore

  2. Nuffield Department of Medicine, NIHR Biomedical Research Centre, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, Oxford, UK

    A K Simon

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Correspondence to A M Gallimore.

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Gallimore, A., Simon, A. Positive and negative influences of regulatory T cells on tumour immunity. Oncogene 27, 5886–5893 (2008). https://doi.org/10.1038/onc.2008.269

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