The Argonaute-1 (Ago1) protein bound to small interfering RNAs (siRNAs) directs heterochromatin formation in fission yeast. A high-throughput sequencing approach reveals that the composition of the Ago1-bound siRNA population is sensitive to the noncanonical poly(A) polymerase Cid14, indicating that the RNA-interference and Cid14-TRAMP RNA-degradation pathways compete for substrates in fission yeast.
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Thon, G. Competing to destroy: a fight between two RNA-degradation systems. Nat Struct Mol Biol 15, 1001–1002 (2008). https://doi.org/10.1038/nsmb1008-1001
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DOI: https://doi.org/10.1038/nsmb1008-1001