Controlling the ability of retrotransposons to replicate and reinsert within the genome is important for maintaining the integrity of genetic information. For the first time, it has been shown that naturally occurring small interfering RNAs exist in human cells and derive from the L1 retrotransposon, providing evidence that RNA interference has a role in regulation of retrotransposition in humans.
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References
Meister, G. & Tuschl, T. Nature 431, 343–349 (2004).
Yang, N. & Kazazian, H.H. Nat. Struct. Mol. Biol. 13, 763–771 (2006).
Soifer, H.S., Zaragoza, A., Peyvan, M., Behlke, M.A. & Rossi, J.J. Nucleic Acids Res. 33, 846–856 (2005).
Deininger, P.L. & Batzer, M.A. Genome Res. 12, 1455–1465 (2002).
Brouha, B. et al. Proc. Nat. Acad. Sci. USA 100, 5280–5285 (2003).
Swergold, G.D. Mol. Cell. Biol. 10, 6718–6729 (1990).
Speek, M. Mol. Cell. Biol. 21, 1973–1985 (2001).
Weisenberger, D.J. et al. Nucleic Acids Res. 33, 6823–6836 (2005).
Bogerd, H.P. et al. Proc. Nat. Acad. Sci. USA 103, 8780–8785 (2006).
Muckenfuss, H. et al. J. Biol. Chem. 281, 22161–22172 (2006).
Stenglein, M.D. & Harris, R.S. J. Biol. Chem. 281, 16837–16841 (2006).
Ketting, R.F., Haverkamp, T.H., van Luenen, H.G. & Plasterk, R.H. Cell 99, 133–141 (1999).
Soifer, H.S. J. Biomed. Biotechnol. 2006, 29049 (2006).
Nolan, T. et al. Nucleic Acids Res. 33, 1564–1573 (2005).
Skowronski, J. & Singer, M.F. Proc. Nat. Acad. Sci. USA 82, 6050–6054 (1985).
Girard, A., Sachidanandam, R., Hannon, G.J. & Carmell, M.A. Nature 442, 199–202 (2006).
Watanabe, T. et al. Genes Dev. 20, 1732–1743 (2006).
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Soifer, H., Rossi, J. Small interfering RNAs to the rescue: blocking L1 retrotransposition. Nat Struct Mol Biol 13, 758–759 (2006). https://doi.org/10.1038/nsmb0906-758
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DOI: https://doi.org/10.1038/nsmb0906-758
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