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Four p(53)s in a pod

Nature Structural & Molecular Biology volume 17, pages 390–391 (2010)Cite this article

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The tumor suppressor p53 protects the cell from cellular stress, and in so doing it decides between cell-cycle arrest and cell death. The high-resolution structure of four DNA binding domains of p53 in complex with DNA shows how the structural collaboration between protein and DNA may influence the biological outcomes of the tumor suppressor.

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Figure 1: Schematic representation of type I and type II architectures.

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Authors and Affiliations

  1. Department of Medical Biophysics, Seth Chitayat and Cheryl H. Arrowsmith are at the Ontario Cancer Institute and the Campbell Family Cancer Research Institute, University of Toronto, Toronto, Ontario, Canada.,

    Seth Chitayat & Cheryl H Arrowsmith

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  1. Seth Chitayat
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  2. Cheryl H Arrowsmith
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Correspondence to Cheryl H Arrowsmith.

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The authors declare no competing financial interests.

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Chitayat, S., Arrowsmith, C. Four p(53)s in a pod. Nat Struct Mol Biol 17, 390–391 (2010). https://doi.org/10.1038/nsmb0410-390

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