The ryanodine receptor (RyR), an ion channel regulating intracellular calcium release in excitable cells, has been challenging for structural analysis because of its colossal proportions compared to most other ion channels. Three independent groups have now used recent technological advancements in single-particle cryo-EM to make giant strides in solving the structure of this elusive protein complex.
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Kuo, I., Ehrlich, B. Muscling in on the ryanodine receptor. Nat Struct Mol Biol 22, 106–107 (2015). https://doi.org/10.1038/nsmb.2960
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DOI: https://doi.org/10.1038/nsmb.2960