New structural analyses suggest two different models for poly(ADP-ribose) polymerase 1 (PARP1) activation by single- and double-strand DNA breaks, providing evidence for PARP1 activation in cis and in trans.
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Coquelle, N., Glover, J. PARP pairs up to PARsylate. Nat Struct Mol Biol 19, 660–661 (2012). https://doi.org/10.1038/nsmb.2306
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DOI: https://doi.org/10.1038/nsmb.2306