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Capture of an early fusion-active conformation of HIV-1 gp41

Nature Structural Biology volume 5, pages 276–279 (1998)Cite this article

An Erratum to this article was published on 01 July 1998

Abstract

Using an inhibitory synthetic peptide (DP-178) from HIV-1 gp41, we have trapped HIV-1 envelope glycoprotein (Env) undergoing conformational changes during virus entry. Our data show that DP-178 binds gp41 and inhibits Env-mediated membrane fusion after gp120 interacts with cellular receptors, indicating that conformational changes involving the coiled coil domain of gp41 are required for entry. Capture of this fusion-active conformation of Env provides insights into the early events leading to Env-mediated membrane fusion.

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Authors and Affiliations

  1. Office of Vaccines, Center for Biologics Evaluation and Research (CBER), Food and Drug Administration (FDA), Bldg. 29, Room 532, HFM-413, 29 Lincoln Dr., Bethesda, Maryland, 20892-4555, USA

    Rika A. Furuta, Yongkai Weng & Carol D. Weiss

  2. Biotech Research Laboratories, 217 Perry Parkway, Gaithersburg, Maryland, 20877, USA

    Carl T. Wild

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  1. Rika A. Furuta
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  2. Carl T. Wild
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  3. Yongkai Weng
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  4. Carol D. Weiss
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Correspondence to Carol D. Weiss.

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Furuta, R., Wild, C., Weng, Y. et al. Capture of an early fusion-active conformation of HIV-1 gp41. Nat Struct Mol Biol 5, 276–279 (1998). https://doi.org/10.1038/nsb0498-276

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