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Prostate cancer

Cardiac mortality associated with ADT plus radiotherapy

Androgen deprivation combined with external beam radiotherapy improves the overall survival of patients with localized prostate cancer but might be associated with adverse effects that influence their health and quality of life. When considering this medication, clinicians must be aware of the increased risk of cardiac mortality in patients with moderate or severe comorbidity.

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References

  1. D'Amico, A. V., Chen, M. H., Renshaw, A. A., Loffredo, M. & Kantoff, P. W. Long-term follow-up of a randomized trial of radiation with or without androgen deprivation therapy for localized prostate cancer. JAMA 314, 1291–1293 (2015).

    Article  Google Scholar 

  2. D'Amico, A. V., Chen, M. H., Renshaw, A. A., Loffredo, M. & Kantoff, P. W. Androgen suppression and radiation versus radiation alone for prostate cancer: a randomized trial. JAMA 299, 289–295 (2008).

    CAS  PubMed  Google Scholar 

  3. Sean O'Farrell, S. et al. Risk and timing of cardiovascular disease after androgen-deprivation therapy in men with prostate cancer. J. Clin. Oncol. 33, 1243–1251 (2015).

    Article  Google Scholar 

  4. Efstathiou, J. A. et al. Cardiovascular mortality after androgen deprivation therapy for locally advanced prostate cancer. J. Clin. Oncol. 27, 92–99 (2008).

    Article  Google Scholar 

  5. Bolla, M. et al. External irradiation with or without long-term androgen suppression for prostate cancer with high metastatic risk: 10-year results of an EORTC randomised study. Lancet Oncol. 11, 1066–1073 (2010).

    Article  CAS  Google Scholar 

  6. Efstathiou, J. A. et al. Cardiovascular mortality and duration of androgen deprivation for locally advanced prostate cancer: analysis of RTOG 92-02. Eur. Urol. 54, 816–824 (2008).

    Article  CAS  Google Scholar 

  7. Bolla, M. et al. Duration of androgen suppression in the treatment of prostate cancer. N. Engl. J. Med. 360, 2516–2527 (2009).

    Article  CAS  Google Scholar 

  8. Nguyen, P. L. et al. Association of androgen deprivation therapy with cardiovascular death in patients with prostate cancer: a meta-analysis of randomized trials. JAMA 306, 2359–2366 (2011).

    Article  CAS  Google Scholar 

  9. Nguyen, P. L. et al. Influence of androgen deprivation therapy on all causes mortality in men with high risk prostate cancer and a history of a congestive heart failure or myocardial infarction. Int. J. Radiat. Oncol. Biol. Phys. 82, 1411–1416 (2012).

    Article  Google Scholar 

  10. Levine, G. N. et al. Androgen-deprivation therapy in prostate cancer and cardiovascular risk: a science advisory from the American Heart Association, American Cancer Society, and American Urological Association: endorsed by the American Society for Radiation Oncology. Circulation 121, 833–840 (2010).

    Article  Google Scholar 

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Correspondence to Michel Bolla.

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Competing interests

M.B. declares that he has received travel support from Janssen and Ipsen and that he has received lecture fees from AstraZeneca. G.C. declares no competing interests.

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Bolla, M., Créhange, G. Cardiac mortality associated with ADT plus radiotherapy. Nat Rev Urol 13, 128–129 (2016). https://doi.org/10.1038/nrurol.2015.295

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