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Prostate cancer

Novel xenografts in mice—a new wave of preclinical models

Nature Reviews Urology volume 12, pages 540–541 (2015)Cite this article

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Robust preclinical models of prostate cancer are required as clinical management of men with this disease evolves, and increasing genomic understanding makes currently available cell lines less relevant. A novel orthotopic xenograft mouse model is state of the art for preclinical models of prostate cancer.

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References

  1. Saar, M. et al. Orthotopic tumorgrafts in nude mice: a new method to study human prostate cancer. Prostate http://dx.doi.org/10.1002/pros.23027.

  2. Sweeney, C. et al. Impact on overall survival (OS) with chemohormonal therapy versus hormonal therapy for hormone-sensitive newly metastatic prostate cancer (mPrCa): an ECOG-led phase III randomized trial. J. Clin. Oncol. 32 (5s suppl.), abstr. LBA2 (2014).

    Article  Google Scholar 

  3. de Bono, J. et al. Abiraterone and increased survival in metastatic prostate cancer. N. Engl. J. Med. 364, 1995–2005 (2011).

    Article  CAS  Google Scholar 

  4. Ware, K. E. et al. Biologic and clinical significance of androgen receptor variants in castration resistantprostate cancer. Endocr. Relat. Cancer. 21, T87–T103 (2014).

    Article  CAS  Google Scholar 

  5. Beer, T. M. et al. Enzalutamide in metastatic prostate cancer before chemotherapy. N. Engl. J. Med. 371, 424–433 (2014).

    Article  Google Scholar 

  6. Lawrence, M. G. et al. A preclinical xenograft model of prostate cancer using human tumors. Nat. Protoc. 8, 836–848 (2013).

    Article  CAS  Google Scholar 

  7. Taylor, R. A. et al. Formation of human prostate tissue from embryonic stem cells. Nat. Methods 3, 179–181 (2006).

    Article  CAS  Google Scholar 

  8. Kantoff, P. W. et al. Sipuleucel-T immunotherapy for castration-resistant prostate cancer. N. Engl. J. Med. 363, 411–422 (2010).

    Article  CAS  Google Scholar 

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Authors and Affiliations

  1. Department of Anatomy and Developmental Biology, Monash University, Level 3, 19 Innovation Walk, Melbourne, 3800, VIC, Australia

    Gail P. Risbridger

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  1. Gail P. Risbridger
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Correspondence to Gail P. Risbridger.

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The author declares no competing financial interests.

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Risbridger, G. Novel xenografts in mice—a new wave of preclinical models. Nat Rev Urol 12, 540–541 (2015). https://doi.org/10.1038/nrurol.2015.198

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