Clinical staging of muscle-invasive bladder cancer remains limited by volume criteria used to identify nodal metastases. The development of accurate predictive models that identify patients at high risk of nodal disease, such as the one described here, is essential to optimize treatment planning for this group of patients.
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References
Shariat, S. F. et al. Discrepancy between clinical and pathologic stage: impact on prognosis after radical cystectomy. Eur. Urol. 51, 137–149 (2007).
Stein, J. P. et al. Radical cystectomy in the treatment of invasive bladder cancer: long-term results in 1,054 patients. J. Clin. Oncol. 19, 666–675 (2001).
Karakiewicz, P. I. et al. Precystectomy nomogram for prediction of advanced bladder cancer stage. Eur. Urol. 50, 1254–1260 (2006).
Resnick, M. J. et al. Longitudinal evaluation of the concordance and prognostic value of lymphovascular invasion in transurethral resection and radical cystectomy specimens. BJU Int. 107, 46–52 (2011).
Shariat, S. F. et al. Predictive value of combined immunohistochemical markers in patients with pT1 urothelial carcinoma at radical cystectomy. J. Urol. 182, 78–84 (2009).
Dyrskjot, L. et al. Gene expression signatures predict outcome in non-muscle-invasive bladder carcinoma: a multicenter validation study. Clin. Cancer Res. 13, 3545–3551 (2007).
Smith, S. C. et al. A 20-gene model for molecular nodal staging of bladder cancer: development and prospective assessment. Lancet Oncol. 12, 137–143 (2011).
Ginsburg, G. S. & Willard, H. F. Genomic and personalized medicine: foundations and applications. Transl. Res. 154, 277–287 (2009).
Shah, J. B., McConkey, D. J. & Dinney, C. P. New strategies in muscle invasive bladder cancer: on the road to personalized medicine. Clin. Cancer Res. doi:10.1158/1078-0432.CCR-10-2770.
Morris, D. S. et al. Understanding bladder cancer death: tumor biology versus physician practice. Cancer 115, 1011–1020 (2009).
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Resnick, M., Guzzo, T. Improvements in clinical staging of muscle-invasive bladder cancer. Nat Rev Urol 8, 360–361 (2011). https://doi.org/10.1038/nrurol.2011.69
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DOI: https://doi.org/10.1038/nrurol.2011.69
