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Vasculitis syndromes

Peripheral neuropathy in AAV—when vasculitis hits a nerve

Peripheral neuropathy can be a manifestation of small-vessel vasculitides such as antineutrophil cytoplasmic antibody-associated vasculitis. Diagnosing vasculitic neuropathy is, however, difficult in many cases. Early treatment focused on achieving remission of the underlying vasculitic process is important as chronic neuropathy has a major influence on a patient's quality of life.

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References

  1. Suppiah, R. et al. Peripheral neuropathy in ANCA-associated vasculitis: outcomes from the European Vasculitis Study Group trials. Rheumatology (Oxford) 10.1093/rheumatology/ker266.

  2. de Groot, K., Schmidt, D. K., Arlt, A. C., Gross, W. L. & Reinhold-Keller, E. Standardized neurologic evaluations of 128 patients with Wegener granulomatosis. Arch. Neurol. 58, 1215–1221 (2001).

    Article  CAS  Google Scholar 

  3. Walsh, M. et al. Health-related quality of life in patients with newly diagnosed antineutrophil cytoplasmic antibody-associated vasculitis. Arthritis Care Res. (Hoboken) 63, 1055–1061 (2011).

    Article  Google Scholar 

  4. Florica, B. et al. Peripheral neuropathy in patients with systemic lupus erythematosus. Semin. Arthritis Rheum. 41, 203–211 (2011).

    Article  Google Scholar 

  5. Rai, V. M., Shenoi, S. D., Pai, S. B. & Choondlal, V. J. Systemic lupus erythematosus (SLE) presenting with peripheral neuropathy: a rare occurrence. Dermatol. Online J. 11, 43 (2005).

    PubMed  Google Scholar 

  6. Said, G. & Lacroix, C. Primary and secondary vasculitic neuropathy. J. Neurol. 252, 633–641 (2005).

    Article  Google Scholar 

  7. Collins, M. P. et al. Peripheral Nerve Society Guideline on the classification, diagnosis, investigation, and immunosuppressive therapy of non-systemic vasculitic neuropathy: executive summary. J. Peripher. Nerv. Syst. 15, 176–184 (2010).

    Article  Google Scholar 

  8. Collins, M. P., Periquet-Collins, I., Sahenk, Z. & Kissel, J. T. Direct immunofluoresence in vasculitic neuropathy: specificity of vascular immune deposits. Muscle Nerve 42, 62–69 (2010).

    Article  Google Scholar 

  9. Kennedy, W. R. et al. A new device to quantify tactile sensation in neuropathy. Neurology 76, 1642–1649 (2011).

    Article  CAS  Google Scholar 

  10. Malpass, K. Peripheral neuropathy: discovering the 'Bumps': a new method to measure symptoms of peripheral neuropathy. Nat. Rev. Neurol. 21, 358 (2011).

    Article  Google Scholar 

Download references

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Correspondence to Cees G. M. Kallenberg.

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Rutgers, A., Kallenberg, C. Peripheral neuropathy in AAV—when vasculitis hits a nerve. Nat Rev Rheumatol 8, 127–128 (2012). https://doi.org/10.1038/nrrheum.2011.184

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