Low cerebral blood flow (CBF) is associated with poor cognitive performance in patients with Alzheimer disease (AD), a new report in Alzheimer's & Dementia indicates. The study included patients with AD (n = 161), mild cognitive impairment (n = 95) and subjective cognitive decline (n = 43). CBF reduction was found to correlate with cognitive decline in the participants with AD, but not in the other two groups. The authors propose that CBF could be used as a marker of disease severity in AD.
References
Leeuwis, A. E. et al. Lower cerebral blood flow is associated with impairment in multiple cognitive domains in Alzheimer's disease. Alzheimers Dement. http://dx.doi.org/10.1016/j.jalz.2016.08.013 (2016)
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Wood, H. Cerebral blood flow could be a marker for Alzheimer disease severity. Nat Rev Neurol 12, 615 (2016). https://doi.org/10.1038/nrneurol.2016.157
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DOI: https://doi.org/10.1038/nrneurol.2016.157
