A new study suggests that changes on diffusion tensor imaging might be useful biomarkers for frontotemporal dementia (FTD). Mahoney et al. conducted two scans approximately 1 year apart in 23 patients with FTD and 18 controls. FTD-specific changes between the two scans were most pronounced for fractional anisotropy in the right paracallosal cingulum, which could be used to classify participants with 94% specificity and 63% sensitivity.