Results from a prospectively followed cohort of patients with Parkinson disease (PD) indicate that although deep brain stimulation (DBS) of the subthalamic nucleus is associated with long-term benefits in tremor reduction, it is far less effective for preventing bradykinesia or postural and gait disturbances. These 'nondopaminergic' motor symptoms of PD progressed at approximately the same rate, regardless of DBS, over a follow-up of 6–9 years.
References
Lilleeng, B. et al. Motor symptoms after deep brain stimulation of the subthalamic nucleus. Acta Neurol. Scand. 10.1111/ane.12342
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Deep brain stimulation does not provide long-term benefit to postural and gait disturbances in Parkinson disease. Nat Rev Neurol 10, 673 (2014). https://doi.org/10.1038/nrneurol.2014.222
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DOI: https://doi.org/10.1038/nrneurol.2014.222