Selective inhibitors of nuclear export (SINEs) might offer hope for patients with glioblastoma. Green et al. found that SINEs, such as KPT-276, slowed down the growth of patient-derived glioblastoma neurosphere cultures, and prolonged survival in glioblastoma mouse model grafted with patient-derived glioblastoma cells. Because KPT-276 has excellent brain penetration and has been previously investigated for treatment of other forms of cancer, the researchers have initiated a clinical trial in patients with relapsed glioblastoma.
References
Green, A. L. et al. Preclinical antitumor efficacy of selective exportin 1 inhibitors in glioblastoma. Neuro-Oncology 10.1093/neuonc/nou303
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Nuclear export protein inhibitors could limit glioblastoma growth. Nat Rev Neurol 10, 674 (2014). https://doi.org/10.1038/nrneurol.2014.218
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DOI: https://doi.org/10.1038/nrneurol.2014.218
