Prophylactic use of paracetamol should be discouraged in patients in the acute phase of ischaemic stroke who do not experience stroke-associated pain or fever, according to a new retrospective study. The findings—based on data from 6,015 patients with ischaemic stroke, 2,435 of whom had received paracetamol—show that paracetamol treatment within 3 days of stroke was associated with poor functional outcome at 90 days in patients without fever or pain. However, paracetamol use had no effect on stroke outcome in individuals who did experienced pain and/or fever.