Parkinson disease (PD) is characterized by destruction of dopaminergic neurons in the substantia nigra, but death of neurons in other brain areas in this disease is less well understood. A study in 15 rapidly autopsied PD brains has shown upregulated signalling via the proapoptotic protein Bid in the temporal cortex compared with that of age-matched controls. Such cortical pathology might have a role in PD-associated cognitive decline.
ORIGINAL RESEARCH PAPER
Jiang, H. et al. Bid signal pathway components are identified in the temporal cortex with Parkinson disease. Neurology 79, 1767–1773 (2012)
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Cortical neurodegeneration in Parkinson disease—role for apoptotic pathways. Nat Rev Neurol 8, 659 (2012). https://doi.org/10.1038/nrneurol.2012.233
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DOI: https://doi.org/10.1038/nrneurol.2012.233