The SYMPLICITY HTN-3 single-blinded, randomized sham-controlled trial, which included 535 patients with resistant hypertension, showed no significant difference in change in office systolic blood pressure or 24 h ambulatory systolic blood pressure from baseline at 6 months in renal denervation and sham-control groups. These findings are in contrast to promising data from unblinded studies that report a reduction in blood pressure after renal denervation in patients with resistant hypertension.