The SYMPLICITY HTN-3 single-blinded, randomized sham-controlled trial, which included 535 patients with resistant hypertension, showed no significant difference in change in office systolic blood pressure or 24 h ambulatory systolic blood pressure from baseline at 6 months in renal denervation and sham-control groups. These findings are in contrast to promising data from unblinded studies that report a reduction in blood pressure after renal denervation in patients with resistant hypertension.
References
Bhatt, D. L. et al. A controlled trial of denervation for resistant hypertension. N. Engl. Jnl. Med. 10.11056/NEJMoa1402670
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SYMPLICITY HTN-3 trial shows no significant effect of renal denervation on systolic blood pressure. Nat Rev Nephrol 10, 299 (2014). https://doi.org/10.1038/nrneph.2014.72
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DOI: https://doi.org/10.1038/nrneph.2014.72