Using polygenic models constructed from genome-wide association study data, researchers have shown that polygenic scores that correlate with high estimated glomerular filtration rate are associated with a reduced risk of large artery atherosclerosis. They suggest that the association between renal disease and stroke might be due to shared genetic factors, which may differ depending on the ischaemic stroke subtype.
References
Holliday, E. G. et al. Polygenic overlap between kidney function and large artery atherosclerotic stroke. Stroke 10.1161/STROKEAHA.114.006609
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Genetic association between renal function and stroke. Nat Rev Nephrol 11, 2 (2015). https://doi.org/10.1038/nrneph.2014.211
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DOI: https://doi.org/10.1038/nrneph.2014.211