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Glomerular disease

Limiting autoimmune tissue injury: ROS and the inflammasome

Nature Reviews Nephrology volume 10, pages 545–546 (2014)Cite this article

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Schreiber et al. have identified an unexpected immunoregulatory role of reactive oxygen species in antineutrophil cytoplasmic antibody-associated crescentic glomerulonephritis. Here, we discuss these findings in view of other pathways with well-known immunostimulatory roles in kidney disease that have recently been shown to have additional immunosuppressive effects.

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Figure 1: Immunoregulatory roles of ROS, NLRP3 and ASC.

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Authors and Affiliations

  1. Division of Nephrology, Medizinische Klinik und Poliklinik IV, Klinikum der Universität München, Ziemssenstraße 1, Munich, D-80336, Germany

    Santhosh V. R. Kumar & Hans-Joachim Anders

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  1. Santhosh V. R. Kumar
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  2. Hans-Joachim Anders
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Correspondence to Hans-Joachim Anders.

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The authors declare no competing financial interests.

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Kumar, S., Anders, HJ. Limiting autoimmune tissue injury: ROS and the inflammasome. Nat Rev Nephrol 10, 545–546 (2014). https://doi.org/10.1038/nrneph.2014.156

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