IgA nephropathy is the most common kidney disease diagnosed in biopsy samples from patients with inflammatory bowel disease (IBD), according to new findings. In a retrospective case series of kidney biopsy samples from 83 patients with IBD, 24% of patients were diagnosed with IgA nephropathy, 19% with interstitial nephritis, 12% with arterionephrosclerosis, 8% with acute tubular injury, 7% with proliferative glomerulonephritis and 5% with minimal-change disease. Moreover, the diagnostic prevalence of IgA nephropathy was higher in the IBD kidney biopsy samples than in 33,630 non-IBD kidney biopsy samples obtained during the same time period (24% versus 8%, P <0.001).
References
Ambruzs, J. M. et al. The histopathologic spectrum of kidney biopsies in patients with inflammatory bowel disease. Clin. J. Am. Soc. Nephrol. 10.2215/CJN.04660513
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Kidney disease in patients with IBD. Nat Rev Nephrol 10, 64 (2014). https://doi.org/10.1038/nrneph.2013.264
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DOI: https://doi.org/10.1038/nrneph.2013.264