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Salt wasting in distal renal tubular acidosis—new look, old problem

Nature Reviews Nephrology volume 9, pages 712–713 (2013)Cite this article

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Acidosis affects sodium and potassium excretion, likely via the pH sensitivity of ion transporters. A recent paper shows that β-intercalated cells with deleted H+-ATPase release ATP into urine, which induces the production of prostaglandin E2 (PGE2). PGE2 then reduces sodium absorption in the principal cells of the cortical collecting tubule and increases potassium secretion.

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  1. Departments of Medicine and Physiology, and Cellular Biophysics, College of Physicians & Surgeons of Columbia University, 630 West 168th Street, New York, 10032, NY, USA

    Qais Al-Awqati

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  1. Qais Al-Awqati
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Al-Awqati, Q. Salt wasting in distal renal tubular acidosis—new look, old problem. Nat Rev Nephrol 9, 712–713 (2013). https://doi.org/10.1038/nrneph.2013.235

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