Researchers report a new genetic variant that contributes to warfarin dose requirement in African American individuals. In a genome-wide association study of adult African Americans, Perera et al. identified a novel CYP2C single nucleotide polymorphism (SNP) that is associated with warfarin dose requirement. The researchers confirmed the association in a validation cohort and say that including this variant in pharmacogenetic dosing algorithms could improve warfarin dose prediction in this patient population.
ORIGINAL RESEARCH PAPER
Perera, M. A. et al. Genetic variants associated with warfarin dose in African-American individuals: a genome-wide association study. Lancet doi:10.1016/S0140-6736(13)60681-9
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CYP2C SNP associated with warfarin dose requirement in African American individuals. Nat Rev Nephrol 9, 432 (2013). https://doi.org/10.1038/nrneph.2013.114
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DOI: https://doi.org/10.1038/nrneph.2013.114