Childhood-onset minimal-change nephrotic syndrome—usually considered a relatively benign disorder confined to childhood—is increasingly being appreciated to continue into adulthood in a sizeable minority of patients. Despite generally excellent preservation of kidney function, treatment-related morbidity may be considerable in these patients.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 12 print issues and online access
$209.00 per year
only $17.42 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
References
Trompeter, R. S., Lloyd, B. W., Hicks, J., White, R. H. R. & Cameron, J. S. Long-term outcome for children with minimal-change nephrotic syndrome. Lancet 1, 368–370 (1985).
Kyrieleis, H. A. C. et al. Long-term outcome of biopsy-proven, frequently relapsing minimal-change nephrotic syndrome in children. Clin. J. Am. Soc. Nephrol. 4, 1593–1600 (2009).
Rüth, E.-M., Kemper, M. J., Leuman, E. P., Laube, G. F. & Neuhaus, T. Children with steroid-sensitive nephrotic syndrome come of age: long-term outcome. J. Pediatr. 147, 202–207 (2005).
Fakhouri, F. et al. Steroid-sensitive nephrotic syndrome: from childhood to adulthood. Am. J. Kidney Dis. 41, 550–557 (2003).
Lahdenkari, A.-T. et al. Clinical features and outcome of childhood minimal change nephrotic syndrome: is genetics involved? Pediatr. Nephrol. 20, 1073–1080 (2005).
Trompeter, A. S., Evans, P. R. & Barratt, T. M. Gonadal function in boys with steroid-responsive nephrotic syndrome treated with cyclophosphamide for short periods. Lancet 1, 1177–1179 (1981).
Su, H. I. et al. Association of cyclophosphamide drug-metabolizing enzyme polymorphisms and chemotherapy-related ovarian failure in breast cancer survivors. Fertil. Steril. doi: 10.1016/j.fertnstert.2009.03.034
Löwik, M. et al. Bigenic heterozygosity and the development of steroid-resistant focal segmental glomerulosclerosis. Nephrol. Dial. Transplant. 23, 3146–3151 (2008).
Lemley, K. V. Yet more ways to skin a cat: nephrin mutations outside the neonatal period. J. Am. Soc. Nephrol. 19, 1837–1838 (2008).
Author information
Authors and Affiliations
Ethics declarations
Competing interests
The author declares no competing financial interests.
Rights and permissions
About this article
Cite this article
Lemley, K. How 'minimal' are the adult consequences of childhood MCNS?. Nat Rev Nephrol 6, 70–71 (2010). https://doi.org/10.1038/nrneph.2009.223
Issue Date:
DOI: https://doi.org/10.1038/nrneph.2009.223
