Fortress et al. examined whether WNT signalling, which regulates hippocampal synaptic function, is involved in hippocampal memory formation. Mice were trained in a hippocampus-dependent object recognition task. After training, they received an infusion of vehicle or dickkopf-related protein 1 (DKK1), a canonical WNT signalling inhibitor, into the dorsal hippocampus. The next day, DKK1-treated mice did not recognize the object from the task, indicating that object recognition memory consolidation involves canonical WNT signalling.
References
Fortress, A. M. et al. Canonical Wnt signaling is necessary for object recognition memory consolidation. J. Neurosci. 33, 12619–12626 (2013)
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Yates, D. Recognizing WNT signalling in memory. Nat Rev Neurosci 14, 591 (2013). https://doi.org/10.1038/nrn3583
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DOI: https://doi.org/10.1038/nrn3583
