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Transcription-independent functions of MYC: regulation of translation and DNA replication

Nature Reviews Molecular Cell Biology volume 9, pages 810–815 (2008)Cite this article

Abstract

MYC is a potent oncogene that drives unrestrained cell growth and proliferation. Shortly after its discovery as an oncogene, the MYC protein was recognized as a sequence-specific transcription factor. Since that time, MYC oncogene research has focused on the mechanism of MYC-induced transcription and on the identification of MYC transcriptional target genes. Recently, MYC was shown to control protein expression through mRNA translation and to directly regulate DNA replication, thus initiating exciting new areas of oncogene research.

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Figure 1: The conserved regions of MYC.
Figure 2: Mechanisms of MYC-induced transcription.
Figure 3: Mechanism of MYC-induced mRNA cap methylation.

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Acknowledgements

This work was funded by National Institutes of Health research grants to M.D.C. and a Medical Research Council Career Development Award to V.H.C.

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Authors and Affiliations

  1. Michael D. Cole and Victoria H. Cowling are at the Departments of Pharmacology and Genetics, Dartmouth Medical School, Norris Cotton Cancer Center, One Medical Center Drive, Lebanon, New Hampshire 03756, USA.,

    Michael D. Cole & Victoria H. Cowling

  2. Victoria H. Cowling is also at the Division of Cell Biology and Immunology, College of Life Sciences, University of Dundee, Dow Street, Dundee, DD1 5EH, UK.,

    Victoria H. Cowling

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Correspondence to Michael D. Cole.

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Cole, M., Cowling, V. Transcription-independent functions of MYC: regulation of translation and DNA replication. Nat Rev Mol Cell Biol 9, 810–815 (2008). https://doi.org/10.1038/nrm2467

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