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Chromatin

A surprise package

Nature Reviews Molecular Cell Biology volume 8, pages 598–599 (2007)Cite this article

...who knows what surprises other specialized nucleosome packages have in store.

Mizuguchi et al. and Camahort et al. isolated Scm3 from an immunopurified Cse4 fraction. Scm3 immunoprecipitated with Cse4 and vice versa, but not with histone H3. Scm3 was also identified by Stoler et al. by screening for dosage suppressors of a conditional cse4 allele. Chromatin immunoprecipitation studies by all groups revealed that Scm3 localizes specifically to centromeres. Using conditional mutants of Scm3 and Cse4, these groups also demonstrated that Cse4 and Scm3 depend on each other for localization to the centromere, which implied that Scm3 is required for centromere formation.

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ORIGINAL RESEARCH PAPERS

  1. Mizuguchi, G. et al. Nonhistone Scm3 and histones CenH3-H4 assemble the core of centromere-specific nucleosomes. Cell 129, 1153–1164 (2007)

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  2. Camahort, R. et al. Scm3 is essential to recruit the histone H3 variant Cse4 to centromeres and to maintain a functional kinetochore. Mol. Cell 26, 853–865 (2007)

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  3. Stoler, S. et al. Scm3, an essential Saccharomyces cerevisiae centromere protein required for G2/M progression and Cse4 localization. Proc. Natl Acad. Sci. USA 104, 10571–10576 (2007)

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Authors
  1. Arianne Heinrichs
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Heinrichs, A. A surprise package. Nat Rev Mol Cell Biol 8, 598–599 (2007). https://doi.org/10.1038/nrm2219

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  • DOI: https://doi.org/10.1038/nrm2219

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