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Tumour suppression

The power of arrest

Nature Reviews Molecular Cell Biology volume 8, pages 514–515 (2007)Cite this article

...cellular senescence as a p53-mediated mechanism of tumour suppression.

Feldser and Greider crossed mice that lacked the RNA component of telomerase (mTR−/−) with a transgenic mouse model of Burkitt's lymphoma that expressed the Myc oncogene in B cells. Tumour formation was suppressed in Myc mTR−/− mice with short telomeres. To investigate whether this effect was due to induction of the apoptotic pathway (as has been demonstrated in other tumour models), the authors disabled the apoptotic pathway by selectively expressing the anti-apoptotic Bcl2 gene in Myc mTR−/− bone marrow cells. Surprisingly, Bcl2-expressing Myc mTR−/− mice with short telomeres were still resistant to tumour formation.

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ORIGINAL RESEARCH PAPERS

  1. Feldser, D. M. & Greider, C. W. Short telomeres limit tumor progression in vivo by inducing senescence. Cancer Cell 11, 461–469 (2007)

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  2. Cosme-Blanco, W. et al. Telomere dysfunction suppresses spontaneous tumorigenesis in vivo by initiating p53-dependent cellular senescence. EMBO Rep. 8, 497–503 (2007)

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Authors
  1. Arianne Heinrichs
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Heinrichs, A. The power of arrest. Nat Rev Mol Cell Biol 8, 514–515 (2007). https://doi.org/10.1038/nrm2200

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